Kuphwanya Bottleneck mu Kunenepa Kwambiri ndi Kuchiza kwa Matenda a Shuga: Kuchita Kwapadera kwa Tirzepatide.

Tirzepatide ndi buku lapawiri la GIP/GLP-1 receptor agonist lomwe lawonetsa lonjezo lalikulu pochiza matenda a metabolic. Potengera zochita za mahomoni awiri achilengedwe a incretin, amathandizira katulutsidwe ka insulin, amapondereza kuchuluka kwa glucagon, komanso amachepetsa kudya - zomwe zimathandiza kuwongolera shuga m'magazi ndikuchepetsa thupi.

Malinga ndi ziwonetsero zovomerezeka, tirzepatide pano ndiyovomerezeka pakuwongolera shuga wamagazi mwa odwala omwe ali ndi matenda amtundu wa 2 komanso kuwongolera kulemera kwanthawi yayitali mwa anthu omwe ali ndi kunenepa kwambiri kapena onenepa kwambiri. Kuchita kwake kwachipatala kumathandizidwa kwambiri ndi maphunziro angapo: mndandanda wa mayesero a SURPASS wasonyeza kuti tirzepatide imachepetsa kwambiri milingo ya HbA1c m'miyeso yosiyanasiyana ndikupambana mankhwala omwe alipo monga semaglutide. Powongolera kulemera, mayesero a SURMOUNT adapereka zotsatira zochititsa chidwi-odwala ena adapeza pafupifupi 20% kuchepetsa kulemera kwa thupi mkati mwa chaka, kuika tirzepatide ngati imodzi mwa mankhwala oletsa kunenepa kwambiri pamsika.

Kuphatikiza pa matenda a shuga ndi kunenepa kwambiri, kugwiritsa ntchito kwa tirzepatide kukukulirakulira. Mayesero azachipatala omwe akupitilira akuwunika momwe amagwiritsidwira ntchito pochiza matenda monga non-alcoholic steatohepatitis (NASH), matenda a impso, ndi kulephera kwa mtima. Makamaka, muyeso la gawo 3 la SUMMIT, tirzepatide inawonetsa kuchepa kwakukulu kwa zochitika zokhudzana ndi kulephera kwa mtima pakati pa odwala omwe ali ndi vuto la mtima ndi kagawo kakang'ono ka ejection (HFpEF) ndi kunenepa kwambiri, zomwe zimapereka chiyembekezo chatsopano cha ntchito zambiri zochizira.