Pa nthawi ya 20211-12-06, ife nthawi ya ife, acadia mapepala (Nasdaq: Acad) adalengeza za zotsatira zabwino za chinthu chake cha a III, Trofineetide. Kuyesedwa kwa gawo la gawo, lotchedwa lavenda, limagwiritsidwa ntchito makamaka kuwunika chitetezo cha chitetezero cha Trofineti pochiza retrome (rs). Mitu 189 yokwana 189 idawerengedwa, onse azaka zapakati pa 520 omwe ali ndi ma Rs.
Lavender anali wakhungu kwambiri, wosinthika, wolamulira wolamulidwa ndi masabata 12 okhala ndi mbali zoyambirira za RSAVICEE zoyambira (RSBQ) ndi zoyeserera zachilengedwe (CGI-I), monga asing'anga, motsatana; Chinsinsi Chomaliza Chachiwiri ndi kulumikizana komanso kophiphiritsa kwa makanda ndi ana (ma CSB-DP-ilo)
Zotsatira zake zinawonetsa kuti marofineti anali ndi kusintha kwakukulu m'mapeto ake poyerekeza ndi plado. Zosintha kuchokera pa Basel mu rsbq ya placebo ndi trofinetride pa sabata 12 anali -1.7 vs -5.1 (p = 0.0175); CGI-I Zambiri Zinali 3.8 vs 3.5 (p = 0.0030). Pakadali pano, kusintha kuchokera ku zosawerengeka ku CSBS-DP-i-Yachikhalidwe inali -1.1 ndi -0.1 ya placebo ndi ma trofinitide, motero.
Mapeto ake onse oyamba ndi a Lavender adawonetsa kuthekera kwa marfinatide zochiza ma Rs, ziyenera kudziwika kuti kuchuluka kwa zomwe zimachitika poyerekeza ndi probo, awiriwo anali 2.1%, motsatana. Pakati pawo, zovuta zomwe zinali zovuta kwambiri zinali:
① Diarrhea - Trofinetride anali 80.6% (97.3% yomwe inali yofatsa yodekha) ndi probo habdi 19.1%;
② kusanza - Trofineti anali 26.9% (96% (96% yomwe inali yofatsa kuti ikhale yofatsa) ndipo prosebo anali 9.6%;
Zochitika zazikulu zidachitika mu 3.2% ya maphunziro m'magulu onse awiri.
Maphunziro oyeserera a Lavenda apitiliza kulandira trofineti atamaliza kuyeserera kapena maphunziro a Lilac-2% omwe adamaliza kufufuza kwa Lilac.
Post Nthawi: Feb-17-2022