Melanotan II

Melanotan II API

Melanotan IIndi synthetic cyclic heptapeptide analogue ofα-melanocyte-stimulating hormone (α-MSH), opangidwa kukuyambitsa melanogenesis, kuwonjezeraChitetezo cha UV, ndi modulatekugonana ndi kagayidwe kachakudya. Zimakhala ngati aagonist osasankhaa melanocortin receptors, makamakaChithunzi cha MC1R, Chithunzi cha MC3R,ndiMtengo wa MC4R.

Poyambirira adaphunzira zakekuwotchandiPhotoprotectorkatundu, Melanotan II wasonyezanso zotsatira pakuwonjezera libido, kuchepetsa chilakolako,ndimphamvu yamagetsi, ndikupangitsa kuti ikhale peptide yofufuza zambiri yomwe ili ndi chidwi ndi dermatology, endocrinology, ndi mankhwala ogonana.

Njira Yochitira

Melanotan II imagwira ntchito poyambitsa zolandilira zingapo za melanocortin:

• Chithunzi cha MC1R: Imalimbikitsakupanga melanin→ imawonjezera mtundu wa khungu komanso chitetezo cha UV

• MC3R/MC4R: Wokhudzidwakulamulira chilakolako, kuwonjezera libido,ndimphamvu homeostasis

• Amadutsa chotchinga chamagazi-ubongo, kukhudza njira zapakati za neurohormonal

Kafukufuku ndi Ntchito Zomwe Zingachitike

Ngakhale kuti sanavomerezedwe kuti agwiritsidwe ntchito pachipatala, Melanotan II amaphunziridwa kwambiri pazinthu zotsatirazi:

1. Khungu la Pigmentation & Chitetezo cha UV

• Imalimbikitsaeumelanin kaphatikizidwe, kupita kukufufuta zachilengedwe

• Amaperekazoteteza zithunzipopanda dzuwa

• Zotheka kuchepetsa chiopsezo cha khansa yapakhungu mwa anthu akhungu loyera

2. Kulephera Kugonana

• Kuwonetsedwa kukuonjezera libido ndi chilakolako chogonanamwa amuna ndi akazi

• Anaphunzitsidwa ngati chithandizo chotheka chaErectile dysfunction (ED)kudzera pa MC4R activation

3. Kukula ndi Kulemera Kwambiri

• Mayikuchepetsa njala ndi kudyapogwiritsa ntchito njira za hypothalamic

• Zowonjezera zopezeka mukafukufuku wa kunenepa kwambiri

API Features (wolemba Gentolex Group)

• Kuyera kwakukulu ≥ 99%(HPLC & LC-MS yatsimikiziridwa)

• Zopangidwa kudzerasolid-phase peptide synthesis (SPPS)

• Endotoxin yotsika, zosungunulira zotsalira zochepa

• Ikupezeka muR&D kumlingo wamalonda