Ipamorelin

Ipamorelin API

Ipamorelin ndi pentapeptide kukula kwa hormone yotulutsa peptide (GHRP) yopangidwa ndi ma amino acid asanu (Aib-His-D-2-Nal-D-Phe-Ls-NH₂). Ndiwosankha GHSR-1a agonist yemwe amatha kulimbikitsa katulutsidwe ka kukula kwa hormone (GH) mwapadera kwambiri. Poyerekeza ndi ma GHRP oyambirira (monga GHRP-2 ndi GHRP-6), Ipamorelin imasonyeza bwino kusankha, chitetezo ndi kukhazikika kwa mankhwala popanda kukhudza kwambiri milingo ya mahomoni ena monga cortisol, prolactin kapena ACTH.

Monga API ya peptide yolemekezeka kwambiri, Ipamorelin pakali pano imagwiritsidwa ntchito kwambiri pofufuza zotsutsana ndi ukalamba, kukonzanso masewera, kupititsa patsogolo kufooka kwa mafupa, kuchira pambuyo pa opaleshoni komanso kulamulira kagayidwe kachakudya.

Kafukufuku ndi Njira Zochita

Ipamorelin imalimbikitsa kutulutsidwa kwa endogenous growth hormone (GH) kuchokera ku anterior pituitary mwa kusankha mwanzeru kukula kwa hormone secretion receptor (GHSR-1a) ndikutsanzira zochita za ghrelin. Njira zake zazikulu zamankhwala ndizo:
1. Limbikitsani kutulutsa kwa GH
Ipamorelin imakonda kwambiri GHSR-1a, zomwe zimapangitsa kuti pituitary gland itulutse GH popanda kukhudza kwambiri ACTH kapena cortisol, ndipo imakhala ndi chitetezo chabwino cha endocrine.
2. Limbikitsani kaphatikizidwe ka mapuloteni ndi kukonza ma cell
Mwa kuonjezera milingo ya IGF-1, imalimbikitsa anabolism ya minofu ya minofu, imathandizira kukonza minofu ndi kusinthika, ndipo ndi yoyenera kukonzanso zowawa, kuchira kwa opaleshoni ndi mankhwala odana ndi atrophy.
3. Kupititsa patsogolo kagayidwe kake ndi kugawa mafuta
GH imakhala ndi zotsatira za kulimbikitsa mafuta komanso kusintha kwa insulin. Ipamorelin ikhoza kuthandizira kuwongolera kagayidwe kachakudya ndipo imagwiritsidwa ntchito pofufuza za metabolic syndrome ndi kunenepa kwambiri.
4. Kupititsa patsogolo kachulukidwe ka mafupa ndi anti-kukalamba
GH/IGF-1 axis ikhoza kulimbikitsa mapangidwe a mafupa ndi mineralization. Ipamorelin imasonyeza lonjezo mu anti-osteoporosis, kukonzanso fracture ndi anti-kukalamba.
5. Sinthani kamvekedwe ka circadian ndi kugona bwino
Kutulutsidwa kwa GH nthawi zambiri kumatsagana ndi tulo tofa nato. Kafukufuku wapeza kuti Ipamorelin ikhoza kusintha mosadukiza kamangidwe ka kugona ndikuwongolera mphamvu yakuchira.
Maphunziro a preclinical ndi kutsimikizira mphamvu

Ngakhale akadali pachipatala / oyambirira chipatala, Ipamorelin yasonyeza chitetezo chabwino komanso chothandiza pa zinyama ndi maphunziro ena aumunthu:

Miyezo ya GH imachulukitsidwa kwambiri (chimake mkati mwa mphindi 30, kutha maola angapo)

Palibe zodziwikiratu za pro-cortisol kapena pro-ACTH zotsatira, zotsatira za endocrine zimatha kulamuliridwa

Limbikitsani misala ndi mphamvu (makamaka nyama zachikulire)

Limbikitsani kuchira pambuyo pa opaleshoni komanso kukonzanso minofu

Kuchulukitsa kwa IGF-1 kumathandizira kukonza ma cell komanso kuyankha kwa antioxidant

Kuonjezera apo, Ipamorelin kuphatikizapo GHRH mimetics (monga CJC-1295) m'maphunziro ena adawonetsa zotsatira za synergistic, kupititsa patsogolo kutulutsa kwa GH.
Kupanga kwa API ndi chitsimikizo chamtundu

Ipamorelin API yoperekedwa ndi Gulu lathu la Gentolex imakonzedwa pogwiritsa ntchito njira yapamwamba kwambiri ** Solid phase peptide synthesis process (SPPS) **, ndipo imayeretsedwa bwino ndikuyesedwa bwino, yoyenera kufufuza zasayansi ndi chitukuko komanso kugwiritsa ntchito mapaipi oyambirira a makampani opanga mankhwala.

Zogulitsa zikuphatikiza:

Purity ≥99% (HPLC test)
Palibe endotoxin, zosungunulira zotsalira zochepa, kuipitsidwa kwa ayoni achitsulo otsika
Perekani zolemba zonse zamtundu wabwino: COA, lipoti la kukhazikika, kusanthula kwazinthu zonyansa, ndi zina.
Kupezeka kwa mulingo wa gramu ~ kilogalamu-level