Kuphatikizika kwa sodium

Inclisiran Sodium (API)

Ntchito Yofufuza:
Inclisiran sodium API (Active Pharmaceutical Ingredient) imaphunziridwa makamaka m'munda wa RNA interference (RNAi) ndi mankhwala a mtima. Monga siRNA yokhala ndi mizere iwiri yolunjika ku jini ya PCSK9, imagwiritsidwa ntchito pofufuza zachipatala komanso zachipatala kuti awunike njira zochepetsera jini zochepetsera LDL-C (low-density lipoprotein cholesterol). Imagwiranso ntchito ngati gawo lachitsanzo pakufufuza njira zoperekera siRNA, kukhazikika, komanso njira zochizira za RNA zomwe zimayang'aniridwa ndi chiwindi.

Ntchito:
Inclisiran sodium API imagwira ntchito poletsa jini ya PCSK9 mu hepatocytes, zomwe zimapangitsa kuchepa kwa mapuloteni a PCSK9. Izi zimabweretsa kuchulukitsidwa kwa zolandilira za LDL komanso kuchotsedwa kwakukulu kwa cholesterol ya LDL m'magazi. Kugwira kwake ntchito ngati chotsitsa chotsitsa cholesterol kwa nthawi yayitali kumathandizira kugwiritsidwa ntchito kwake pochiza hypercholesterolemia ndikuchepetsa chiopsezo cha matenda amtima. Monga API, imapanga chigawo chachikulu cha mankhwala opangidwa ndi Inclisiran.