Donilorsen

Donilorsen (API)

Ntchito Yofufuza:
Donilorsen API ndi antisense oligonucleotide (ASO) yomwe ikufufuzidwa pochiza angioedema ya cholowa (HAE) ndi zina zotupa. Amaphunziridwa mu nkhani ya RNA-zochizira, cholinga kuchepetsa kufotokozaplasma prekallikrein(KLKB1 mRNA). Ofufuza amagwiritsa ntchito Donidalorsen kuti afufuze njira zochepetsera ma jini, ma pharmacokinetics omwe amadalira mlingo, komanso kuwongolera kwanthawi yayitali kwa kutupa kwa bradykinin.

Ntchito:
Donidalorsen ntchito ndi kusankha kumanga kutiKLKB1mRNA, kuchepetsa kupanga kwa plasma prekallikrein - enzyme yofunika kwambiri mu kallikrein-kinin system yomwe imayambitsa kutupa ndi kutupa mu HAE. Pochepetsa milingo ya kallikrein, Donidalorsen imathandizira kupewa kuukira kwa HAE ndikuchepetsa kulemetsa kwa matenda. Monga API, imakhala ngati gawo lalikulu lachirengedwe pakupanga chithandizo chanthawi yayitali, choyendetsedwa ndi HAE.