Cagrilintide

Kufotokozera Kwachidule:

Cagrilintide ndi mankhwala, amylin receptor agonist opangidwa kwa nthawi yayitali omwe amapangidwa kuti athe kuchiza kunenepa kwambiri komanso zovuta zokhudzana ndi kagayidwe kachakudya. Potengera mahomoni achilengedwe amylin, amathandizira kuwongolera njala, kuchepa kwa m'mimba, ndikuwonjezera kukhuta. API yathu yoyera kwambiri ya Cagrilintide imapangidwa pogwiritsa ntchito kaphatikizidwe kamankhwala ndipo imakwaniritsa miyezo yamagulu amankhwala, ndikupangitsa kuti ikhale yoyenera kugwiritsidwa ntchito popanga zowongolera zolemera.

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zogulitsa Tags

Cagrilintide API

Cagrilintidendi nthawi yayitali, yopangidwa ndi mankhwalaAmylin receptor agonist, opangidwa ngati mankhwala atsopano akunenepa kwambiri komanso matenda okhudzana ndi kunenepa kwambiri. Amapangidwa kuti azitengera zotsatira zaamylin munthuHormone yopangidwa ndi insulin ndi ma pancreatic β-cell, omwe amagwira ntchito yofunika kwambiri pakuwongolera kudya, kutulutsa m'mimba, komanso kukhuta.

Cagrilintide ikupangidwa ngati akamodzi pamlungu jekeseni mankhwala, kupereka yankho lodalirika kwambirikasamalidwe kulemera kwanthawi zonse, makamaka pamene amagwiritsidwa ntchito mukuphatikiza ndi GLP-1 receptor agonistsmongaSemaglutide.

Njira Yochitira

Cagrilintide imakhala ndi zotsatira zake zochizira pomanga ndi kuyambitsaamylin receptors, zotsogolera ku:

Kuchepetsa chilakolako
Kuchedwetsa kutulutsa m'mimba, zomwe zimatalikitsa kumva kukhuta
Kuchepetsa kudya kwa calorie komanso kuchuluka kwa satiety

Kuwongolera kosiyanasiyana kwa kadyedwe kazakudya kumapangitsa kukhala woyenera kuyang'anirakunenepa kwambiri komanso zovuta zokhudzana ndi cardiometabolic.

Kafukufuku ndi Clinical Data

Cagrilintide yawonetsa zotsatira zabwino m'mayesero angapo azachipatala, kuphatikizaMaphunziro a Phase 2 opangidwa ndi Novo Nordisk:

Pamene ntchitoyekha, Cagrilintide imatsogolera kukuchepa kwa thupi kumadalira mlingo, mpakaKuchepetsa thupi ndi 10.8%.pa masabata 26 mwa anthu onenepa kwambiri.
Litikuphatikiza Semaglutide, zotsatira zochepetsera thupi zimakulitsidwa kwambiri-kukwaniritsakuchepetsa kwambiri kulemera kwa thupi kuposa wothandizira yekha.
Zawonetsayabwino tolerabilityndimbiri yokhazikika yachitetezo, zowawa zambiri zimakhala zizindikiro zochepa za m'mimba.

Njira yophatikizira iyi ndi gawo lofunikira kwambirim'badwo wotsatira wothana ndi kunenepa kwambiri, kulunjika njira zingapo zokhuta (amylin + GLP-1).

Ubwino wa API ndi Kupanga

ZathuCagrilintide API:

Amapangidwa ndi Advancedsolid-phase peptide synthesis (SPPS)ndi kuyera kwakukulu ndi kukhazikika kwa mankhwala
Zapangidwirajekeseni mapangidwe mapangidwe
Kukumana ndi mayikoMiyezo yamankhwala (ICH, GMP, FDA)
Ikupezeka mukuyesa kupanga malonda ang'onoang'ono, yoyenera kugwiritsidwa ntchito kwachipatala ndi mafakitale

Achire Mphamvu

Cagrilintide imayimira amakina atsopanomu kasamalidwe kulemera kupitirira GLP-1 monotherapy. Mbiri yake yowonjezereka imapangitsa kuti ikhale yoyenera:

Odwala onenepa kwambiri komanso onenepa kwambiri(wokhala kapena wopanda shuga)
Chithandizo chophatikizakuti muchepetse thupi
Kukula kwamtsogolo mumetabolic syndrome ndi prediabetes