AEEA-AEEA

AEEA-AEEA (Aminoethoxyethoxyacetate dimer)

Ntchito Yofufuza:
AEEA-AEEA ndi hydrophilic, flexible spacer yomwe imagwiritsidwa ntchito pofufuza peptide ndi mankhwala osokoneza bongo. Zili ndi mayunitsi awiri a ethylene glycol, zomwe zimapangitsa kuti zikhale zothandiza pophunzira zotsatira za kutalika kwa linker ndi kusinthasintha pa kuyanjana kwa maselo, kusungunuka, ndi zochitika zamoyo. Ofufuza nthawi zambiri amagwiritsa ntchito mayunitsi a AEEA kuti awunike momwe ma spacers amakhudzira magwiridwe antchito a antibody-drug conjugates (ADCs), peptide-drug conjugates, ndi ma bioconjugates ena.

Ntchito:
AEEA-AEEA imagwira ntchito ngati cholumikizira cha biocompatible chomwe chimawonjezera kusungunuka, kumachepetsa kutsekeka kwa steric, ndikuwongolera kusinthasintha kwa maselo. Zimathandizira kulekanitsa madera omwe amagwira ntchito mkati mwa molekyulu, monga kulunjika ma ligand ndi katundu wolipira, zomwe zimapangitsa kuti azimanga bwino komanso ntchito. Makhalidwe ake osakhala a immunogenic ndi hydrophilic amathandizanso kuti mbiri ya pharmacokinetic ikhale yabwino pakugwiritsa ntchito achire.