20mg Retatrutide Kuchepetsa Kulemera kwa Peptide Lyophilized Powder Reta Mbale jekeseni 99% Retatrutide

Mafotokozedwe Akatundu
Retatrutide ndi buku lachitatu la agonist peptide lolunjika ku glucagon receptor (GCGR), insulinotropic polypeptide receptor (GIPR) yodalira glucose, ndi glucagon-ngati peptide-1 receptor (GLP-1R). Retatrutide imayatsa GCGR, GIPR, ndi GLP-1R yamunthu yokhala ndi EC50 mikhalidwe ya 5.79, 0.0643, ndi 0.775 nM, motsatana, ndi mbewa GCGR, GIPR, ndi GLP-1R yokhala ndi EC50 mikhalidwe ya 2.32, 0.0.1974, ndi nM1979 Imagwira ntchito ngati chida chofunikira chofufuzira pakufufuza za kunenepa kwambiri komanso zovuta za metabolic.

Retatrutide imayendetsa bwino njira yolumikizira ya GLP-1R ndipo imathandizira katulutsidwe ka insulini yodalira glucose pochita pa GIP ndi GLP-1 receptors. Peptide yopangidwa iyi imawonetsa mphamvu za hypoglycemic ndipo idapangidwa ngati mankhwala oletsa matenda a shuga a Type 2 Diabetes (T2D). Imalimbikitsa kutulutsidwa kwa insulini komanso kupondereza katulutsidwe ka glucagon m'njira yodalira shuga.

Kuonjezera apo, Retatrutide yasonyezedwa kuti imachedwetsa kutulutsa m'mimba, kuchepetsa kusala kudya ndi postprandial shuga, kuchepetsa kudya, ndi kuchititsa kuti thupi likhale lolemera kwambiri mwa anthu omwe ali ndi T2D.

Ntchito Zachilengedwe
Retatrutide (LY3437943) ndi peptide imodzi yokhala ndi lipid-conjugated yomwe imagwira ntchito ngati agonist wamphamvu wa GCGR, GIPR, ndi GLP-1R. Poyerekeza ndi mbadwa za glucagon ndi GLP-1, Retatrutide imawonetsa mphamvu zochepa pa GCGR ndi GLP-1R (0.3 × ndi 0.4 ×, motsatana) koma imawonetsa nyonga yowonjezereka (8.9 ×) pa GIPR poyerekeza ndi insulinotropic polypeptide yodalira shuga (GIP).

Njira Yochitira
M'maphunziro okhudza mbewa za matenda a shuga omwe ali ndi nephropathy, kuwongolera kwa Retatrutide kunachepetsa kwambiri albuminuria ndikuwongolera kusefera kwa glomerular. Kuteteza kumeneku kumachitika chifukwa cha kuyambitsa kwa njira yolumikizira yodalira ya GLP-1R/GR, yomwe imayimira zotsutsana ndi zotupa komanso zotsutsa-apoptotic mu minofu yaimpso.

Retatrutide imathandizanso mwachindunji glomerular permeability, kukulitsa luso la mkodzo. Zotsatira zoyamba zikusonyeza kuti, poyerekeza ndi mankhwala ochiritsira ochiritsira matenda a impso monga ACE inhibitors ndi ARBs, Retatrutide imatulutsa kuchepa kwambiri kwa albuminuria patatha milungu inayi yokha ya chithandizo. Kuphatikiza apo, zawonetsa kuchita bwino kwambiri pakuchepetsa kuthamanga kwa magazi kwa systolic kuposa ma ACE inhibitors kapena ma ARB, popanda zotsatira zoyipa zomwe zawonedwa.

Zotsatira zake
Zotsatira zodziwika bwino za Retatrutide ndi m'mimba mwachilengedwe, kuphatikiza nseru, kutsekula m'mimba, kusanza, ndi kudzimbidwa. Zizindikirozi nthawi zambiri zimakhala zofatsa mpaka zolimbitsa thupi ndipo zimatha kuthana ndi kuchepetsa mlingo. Pafupifupi 7% ya anthu omwe adaphunzira nawo adawonetsanso zowawa zapakhungu. Kuwonjezeka kwa kugunda kwa mtima kunawonedwa pa masabata a 24 m'magulu apamwamba, omwe pambuyo pake anabwerera kumagulu oyambirira.